Single-Dose Azithromycin versus Penicillin G Benzathine for the Treatment of Early Syphilis
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چکیده
منابع مشابه
Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis.
BACKGROUND Pilot studies suggest that a single, 2-g oral dose of azithromycin may be an alternative to a 2.4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country. METHODS A total of 328 subjects, 25 with primary and 303 with high-titer (a titer of at least 1:8 on a rapid p...
متن کاملJarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy
INTRODUCTION The Jarisch-Herxheimer reaction, a febrile inflammatory reaction that often occurs after the first dose of chemotherapy in spirochetal diseases, may result in deleterious effects to patients with neurosyphilis and to pregnant women. A single 2-g oral dose of azithromycin is an alternative treatment to benzathine penicillin G for early syphilis in areas with low macrolide resistance...
متن کاملA single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis.
BACKGROUND Treatment guidelines recommend the use of a single dose of benzathine penicillin G (BPG) for treating early syphilis in human immunodeficiency virus (HIV)-infected persons. However, data supporting this recommendation are limited. We examined the efficacy of single-dose BPG in the US Military HIV Natural History Study. METHODS Subjects were included if they met serologic criteria f...
متن کاملAzithromycin versus penicillin for early syphilis.
n engl j med 354;2 www.nejm.org january 12, 2006 203 is likely to be the cause of bacterial vaginosis and that Koch’s postulates for disease causation are inadequate for describing potential causal relationships in this syndrome. Bacterial vaginosis probably results from infection with complex communities of bacteria that consist of metabolically interdependent (syntrophic) species. Diseases ca...
متن کاملComparison of Doxycycline and Benzathine Penicillin G for the Treatment of Early Syphilis.
Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis. The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effec...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2005
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa044284